货号：555721

品牌：BD Pharmingen

规格：100ug

目录价：￥4043.00

市场价格：￥2547.09

会员价格：￥2223.65

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Catalog Number

555721

Brand

BD Pharmingen™

Name

CD104

Alias

Integrin β₄ chain

Concentration

0.5 mg/ml

Size

0.1mg

RegulatoryStatus

RUO

Clone

450-9D

Format

Purified

Isotype

IgG₁, λ

Reactivity

QC Testing : Human

Applications

Flow cytometry	- Routinely Tested
Immunohistochemistry-frozen	- Tested During Development

Clone - Description

Reacts with integrin b₄ chain, a 205 kDa transmembrane glycoprotein which associates with CD49f (integrin a6 chain) to form the a₆/b₄ (CD49f/CD104) complex. CD104 is expressed on epithelial cells, Schwann cells, and some tumor cells. The CD49f/CD104 complex is located in the hemidesmosomes of the epidermis, suggesting its role in epidermal cell-basement membrane adhesion. The clone 450-9D recognizes the extracellular domain of human CD104 and is able to block the binding of clone 439-9B (another CD104 clone) to A431 cells. 450-9D is effective in flow cytometry and immunohistochemistry on acetone-fixed, frozen tissue sections.^1-7