货号：557666

品牌：BD Pharmingen

规格：1EA

目录价：￥3476.00

市场价格：￥2189.88

会员价格：￥1911.80

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Catalog Number

557666

Brand

BD Pharmingen™

Name

CD3e

Alias

CD3 ε chain

Concentration

0.2 mg/ml

Size

0.1mg

RegulatoryStatus

RUO

Clone

145-2C11

Format

Alexa Fluor® 488

Isotype

IgG₁, κ

W.B. Positive Control

none>br<

Immunogen

H-2Kb specific cytotoxic T lymphocyte clone BM10-37

Reactivity

QC Testing : Mouse

Applications

Flow cytometry

- Routinely Tested

Clone - References

1. Leo, O., M. Foo, D.H. Sachs, L.E. Samelson, and J.A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84: 1374 - 1378.2. Isakov, N., R.L. Wange, W.H. Burgess, J.D. Watts, R. Aebersold, and L.E. Samelson. 1995. ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: The tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity. J. Exp. Med. 181: 375 - 380.3. Nakano, H., T. Yamazaki, S. Miyatake, N. Nozaki, A. Kikuchi, and T. Saito. 1996. Specific interaction of topoisomerase II™ and the CD3e chain of the T cell receptor complex. J. Biol. Chem. 271: 6483 - 6489.4. Portoles, P., J. Rojo, A. Golby, M. Bonneville, S. Gromkowski, L. Greenbaum, C.A. Janeway, Jr., D.B. Murphy, and K. Bottomly. 1989. Monoclonal antibodies to murine CD3- define distinct epitopes, one of which may interact with CD4 during T cell activation. J. Immunol. 142: 4169 - 4175.5. Shinkai, Y., and F.W. Alt. 1994. CD3-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR ™ chain expression. Int. Immunol. 6: 995 - 1001.6. Radvanyi, L.G., G.B. Mills, and R.G. Miller. 1993. Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death. J. Immunol. 150: 5704 - 5715.7. Castro, J.E., J.A. Listman, B.A. Jacobson, Y. Wang, P.A. Lopez, S. Ju, P.W. Finn, and D.L. Perkins. 1996. Fas modulation of apoptosis during negative selection of thymocytes. Immunity 5: 617 - 627.8. Salvadori, S., B. Gansbacher, A.M. Pizzimenti, and K.S. Zier. 1994. Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors. J. Immunol. 153: 5176 - 5182.