货号：557958

品牌：BD Pharmingen

规格：1EA

目录价：￥3351.00

市场价格：￥2111.13

会员价格：￥1843.05

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The 1D3 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 95-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.

Catalog Number

557958

Brand

BD Pharmingen™

Name

CD19

Concentration

0.2 mg/ml

Size

0.1mg

RegulatoryStatus

RUO

Clone

1D3

Format

Alexa Fluor® 700

Isotype

IgG_2a, κ

W.B. Positive Control

none

Immunogen

Mouse CD19 Transfected Cell Line

Strain Host

LEW

Reactivity

QC Testing : Mouse

Applications

Flow cytometry

- Routinely Tested

Images