货号：558382

品牌：BD Pharmingen

规格：100ug

目录价：￥10207.00

市场价格：￥6430.41

会员价格：￥5613.85

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Epidermal Growth Factor (EGF) elicits a variety of cellular responses that are initiated by EGF Receptor (EGFR) binding and activation of intrinsic tyrosine kinase activity. EGFR, also known as ErbB1 or HER1, is a member of the ErbB class of receptor protein tyrosine kinases. It has an extracellular ligand-binding domain, a single transmembrane region, and a cytoplasmic region containing a protein tyrosine kinase domain and a c-terminal regulatory domain with many phosphorylation sites. Following ligand binding, EGFR forms homodimers and heterodimers with ErbB2. Specific C-terminal tyrosine residues are then autophosphorylated and, in turn, bind to adaptor proteins, kinases, or protein tyrosine phosphatases. Specifically, phosphorylated tyrosine 1173 (Y1173) interacts with Shc, SHP1, and PLCg, which mediate downstream signaling cascades and negative feedback regulation of EGFR activation. Inappropriate expression or mutations of EGFR and/or deregulation of its signaling pathways are associated with many types of cancer, making EGFR a promising target for cancer therapies.The 12A3 monoclonal antibody recognizes the phosphorylated Y1173 in the regulatory domain of human EGFR.

Catalog Number

558382

Brand

BD Pharmingen™

Name

EGF Receptor (pY1173)

Concentration

0.5 mg/ml

Size

0.1mg

RegulatoryStatus

RUO

Clone

9H2

Format

Purified

Isotype

IgG₁, κ

W.B. Positive Control

none

Molecular Weight

175 kDa

Immunogen

Phosphorylated Human EGF Receptor Peptide

Reactivity

QC Testing : HumanReported : MouseReported : RatReported : Dog

Applications

ELISA	- Reported
Immunohistochemistry-formalin (antigen retrieval required)	- Reported
Immunoprecipitation	- Reported
Western Blot	- Routinely Tested