货号：558493

品牌：BD Pharmingen

规格：1EA

目录价：￥10269.00

市场价格：￥6469.47

会员价格：￥5647.95

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Cocktail Component Clone IsotypeAPC anti-Rat CD3 1F4 mIgMPE anti-Rat CD4 OX-35 mIgG2aFITC anti-Rat CD8a OX-8 mIgG1The Rat T Lymphocyte Cocktail is a three-color reagent cocktail designed to identify rat T lymphocytes by direct immunofluorescence staining with flow cytometric analysis. The OX-35 antibody reacts with the CD4 antigen on most thymocytes, a subpopulation of mature T lymphocytes (ie, MHC class II-restricted T cells, including most T helper cells), monocytes, macrophages, and some dendritic cells (1,2). The OX-8 antibody reacts with the hinge-like membrane-proximal domain of the 32-kDa alpha chain of the CD8 differentiation antigen (1,4). The CD8a and b chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopuplation of mature T-lymphocytes (ie, MHC class I-restricted T cells, including most T suppressor/cytotoxic cells. The IF4 antibody reacts with the T-cell receptor-associated CD3 cell-surface antigen found on thymocytes and peripheral T lymphocytes (1,3).

References

1. Brideau, R.J.. Two subsets of rat T lymphocytes defined with monoclonal antibodies.. Eur J Immunol. 1980; 10:609-615.2. Jefferies, W.A., J.R. Green, and A.F. Williams. Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages.. J Exp Med. 1985; 162:117-127.3. Tanaka, T., T. Masuko, H. Yagita, T. Tamura, and Y. Hashimoto. Characterization of a Cd3-like rat T cell surface antigen recognized by a monoclonal antibody.. J Immunol. 1989; 142:2791-2795.4. Torres-Nagel, N., E. Kraus, M.H. Brown, et al.. Differntial thymus dependence of rat CD8 isoform expression.. Eur J Immunol. 1992; 22:2841-2848.

Catalog Number

558493

Brand

BD Pharmingen™

Name

Rat T Lymphocyte Cocktail

Size

50Tests

RegulatoryStatus

RUO

Clone	Format	Isotype
1F4	APC	Mouse IgM, κ
OX-35	PE	Mouse IgG2a, κ
OX-8	FITC	Mouse IgG1, κ