货号：558703

品牌：BD Pharmingen

规格：1EA

目录价：￥4902.00

市场价格：￥3088.26

会员价格：￥2696.10

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The GL1 antibody has been reported to react with the B7-2 (CD86) costimulatory molecule expressed on a broad spectrum of leukocytes, including B lymphocytes, T lymphocytes, thioglycollate-induced peritoneal macrophages, dendritic cells and astrocytes. CD86 is expressed at low levels by freshly explanted peripheral B and T cells, and its expression is substantially increased by a variety of T cell- and B cell-specific stimuli with a peak expression after 18-42 hours of culture. In contrast to most naive CD4+ T cells, memory CD4+ T cells express B7-2, both at the mRNA and protein level. CD86, a ligand for CD28 and CD152 (CTLA-4), is one of the accessory molecules that plays an important role in T cell-B cell costimulatory interactions. It has been shown to be involved in immunoglobulin class-switching and triggering of mouse NK cell-mediated cytotoxicity. CD80 (B7-1) is an alternate ligand for CD28 and CD152 (CTLA-4). GL1 antibody reportedly blocks MLR and stimulation of T cells by natural antigen-presenting cells. In addition, a mixture of anti-B7-1 and anti B7-2 (GL1) mAbs reportedly inhibits the in vitro interaction of CTLA-4 with its ligand and the in vivo priming of cytotoxic T lymphocytes.

Catalog Number

558703

Brand

BD Pharmingen™

Name

CD86

Alias

B7-2

Concentration

0.2 mg/ml

Size

0.1mg

RegulatoryStatus

RUO

Clone

GL1

Format

APC

Isotype

IgG_2a, κ

W.B. Positive Control

none

Immunogen

Mouse (CBA/Ca) LPS-activated splenic B Cells

Strain Host

LOU

Reactivity

QC Testing : Mouse

Applications

Flow cytometry

- Routinely Tested