货号：558705

品牌：BD Pharmingen

规格：5mL

目录价：￥9721.00

市场价格：￥6124.23

会员价格：￥5346.55

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Catalog Number

558705

Brand

BD IMag™

Name

CD11c Magnetic Particles - DM

Size

5mL

RegulatoryStatus

RUO

Clone

S-HCL-3

Format

BD IMag™-DM

Isotype

IgG_2b, κ

W.B. Positive Control

none

Reactivity

QC Testing : Human

Applications

Cell separation

- Routinely Tested

CD11c recognizes a human monocyte/ macrophage antigen. CD11c is specific for the Mr 150-kDa α-subunit of the CD11c/CD18 antigen heterodimer, also referred to as complement receptor type 4 (CR₄). The Mr 95-kDa CD18 antigen, the β chain of leucocyte function–associated antigen-1 (LFA-1), is common to the CD11a/CD18 (LFA-1) and CD11b/CD18 antigen heterodimers.The CD11c antigen is present on monocytes and in low density on granulocytes and NK lymphocytes in peripheral blood. It is also present on hairy-cell leukemias and on some acute myeloid leukemias (AML). CD11c reacts with an epitope on the α (150-kDa) chain of the CD11c/CD18 antigen complex. In addition, CD11c stains sinus histiocytes of lymph node, tonsil, and spleen; macrophages in the cortex and medulla of thymus; Kupffer cells in liver; elongated intertubular cells in kidney; and alveolar macrophages in lung tissue. In malignant tissue, the antibody stains true histiocytic lymphomas. It does not stain carcinomas or T or B lymphomas.