货号：180443

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：1 ML

目录价：￥6375.00

市场价格：￥5737.50

会员价格：￥5737.50

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 Full Product DescriptionThis monoclonal antibody is specific for MSH6. Inherited (germline) mutations in DNA mismatch repair genes such as MLH1, MSH2, MSH3, and MSH6 are the major cause of hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. A characteristic of HNPCC tumors is microsatellite instability (MSI). Detection of microsatellite instability in a tumor sample will increase the probability of detecting a germline mutation in a DNA mismatch repair gene from the patient sample. Thus, MSI analysis is usually performed prior to proceeding with full mutation analysis of mismatch repair genes. Immunohistochemical (IHC) analysis of suspected HNPCC tumor samples has come into favor as a means of screening patients who may carry a mutation or a deletion in one of the mismatch repair (MMR) genes. Positive tissue: Colon carcinomaClone_PAD2D4B5ImmunogenRecombinant protein corresponding to the N-terminus of human MSH6SpecificityMSH6ReactivityHuman ApplicationsImmunohistochemistry (FFPE)PretreatmentEpitope Retrieval: Required (EDTA, pH 8.0) Enzyme Digestion: Not Required Staining PatternNuclearStorage2-8°CFor In Vitro Diagnostic UseCE 规格

Reactivity:	Human
Validated Application:	Immunohistochemistry (FFPE)
Host:	Mouse
SubClass (Isotype):	IgG3, kappa
Clonality:	Monoclonal
Target Gene:	MSH6
Gene ID:	2956
Label or Dye:	Unconjugated
Dilution:	Concentrate Antibody
Product Size:	1 mL
Shipping Condition:	Wet Ice

内容及储存 Store in refrigerator (2–8°C).