货号：4464080

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：EACH

目录价：￥4911.00

市场价格：￥4419.90

会员价格：￥4419.90

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 miRNA inhibitors are small, chemically modified single-stranded RNA molecules designed to specifically bind to and inhibit endogenous miRNA molecules and enable miRNA functional analysis by down-regulation of miRNA activity. Life Technologies has now released the second generation of miRNA inhibitors, mirVana™ miRNA Inhibitors, which:• Display better potency than lead competitor's product• Offer maximum and consistent effect in vitro at low miRNA inhibitor concentration• Are non toxic• Target the most updated Sanger content• Can be used in vitro and in vivo, offering consistency throughout your entire research project Positive and negative controls are also available for use along with mirVana™ miRNA Inhibitors in miRNA down-regulation experiments.mirVana™ miRNA Inhibitor let-7c Positive Control The mirVana™ miRNA Inhibitor let-7c Positive Control is intended for use as a positive control for mammalian cell culture experiments using mirVana™ miRNA Inhibitors. Endogenous let-7c miRNA has been shown to negatively regulate HMGA2 mRNA in cultured cells. HMGA2 is a ubiquitously expressed, nonhistone, chromatin protein that can modulate gene expression through changes in chromatin architecture. let-7c miRNA down-regulates levels of HMGA2 mRNA. When transfected into human and mouse cell lines, let-7c miRNA inhibitor blocks endogenous let-7c miRNA, resulting in increased levels of HMGA2 mRNA. Thus, let-7c miRNA inhibitor activity can be monitored in human or mouse cells using real-time reverse transcription PCR (RT-PCR) to detect HMGA2 mRNA.First Generation Inhibitor Controls Our first-generation miRNA inhibitors (and controls), Ambion® Anti-miR™ miRNA Inhibitors, have lower specificity and potency, plus a lower strand specificity compared to the new mirVana™ miRNA Inhibitors. These first-generation inhibitors are recommended for completing ongoing in vitro miRNA studies. For new studies or in vivo studies, we highly recommend our new mirVana™ miRNA Inhibitors and their corresponding controls. 规格

RNAi Type:	Anti-miRNA
Control Type:	Positive Control
Label or Dye:	Unconjugated
Product Size:	5 nmol
Purification:	Purified
Shipping Condition:	Room Temperature

内容及储存 Store at or below –20°C. Do not store in a frost-free freezer.