货号：700012

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UG

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ recombinant rabbit anti-ERK 1/2 [pTpY185/187] monoclonal antibody is specific to human ERK 1/2 [pTpY185/187], and does not recognize non-phosphorylated ERK1/2. Based on sequence identity and similarity, reactivity to mouse, rat, chimpanzee, bovine, chicken, Xenopus, and zebrafish is expected. ERK 1/2 [pTpY185/187] is also known as ERK1: PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A, MGC20180, ERK2: ERK, p38, p40, p41, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, and p41mapk. ABfinity™ recombinant rabbit anti-ERK 1/2 [pTpY185/187] monoclonal antibody is used in Western Blot, Immunofluorescence, Immunohistochemistry and Flow Cytometry.Antibody Specifications:• Applications: Validated applications for this rabbit anti-ERK 1/2 [pTpY185/187] monoclonal antibody are Western Blot, Immunofluorescence, Immunohistochemistry and Flow Cytometry.• Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG.• Clone ID of Monoclonal Antibody (mAb): The rabbit anti-ERK 1/2 [pTpY185/187] monoclonal antibody clone is 15H10L7.• Reactivity: Reacts with human ERK 1/2 [pTpY185/187].• Product Size: Rabbit anti-ERK 1/2 [pTpY185/187] monoclonal antibody is available in a 100 µg size. ERK (extracellular signal-regulated kinase), also known as MAPK (Mitogen-Activated Protein Kinase), has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli, including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth, differentiation and the cytoskeleton. ERK1 and ERK2 are fully activated by phosphorylation within a Thr-Glu-Tyr motif of the activation loop on both a threonine and a tyrosine residue by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of the ERK1&2 enzymes. Aberrant ERK1/2 phosphorylation has been linked to several cancers and may be a useful prognostic marker in some carcinomas. 规格

Reactivity:	Human
Validated Application:	Flow Cytometry,Immunohistochemistry,Immunofluorescence,Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	15H10L7
Antibody Fragment:	Whole Antibody
Target Gene:	ERK1/2 [pT185/pY187]
Gene ID:	5595, 5594
Accession Number:	P27361, P28482
Label or Dye:	Unconjugated
Target Modification State:	Phospho
Purification:	Affinity Purified
Concentration:	0.5 mg⁄ml
Color:	Unconjugated
Form:	Liquid
Neutralizing Antibody:	No
Platform:	Confocal Microscope,Fluorescence Microscope,Flow Cytometer
Product Size:	100 µg
Protein Family:	Kinases & Inhibitors
Quantity:	1
Volume:	200 µl
Research Category:	Signal Transduction
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.