货号：700048

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UG

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ recombinant rabbit anti-SMAD2 monoclonal antibody is specific to human SMAD2. Based on sequence identity and similarity, reactivity to orangutan, bovine, chicken, Xenopus, opossum, mouse, rat, zebrafinch, carp, zebrafish, and goldfish is expected. SMAD2 is encoded by the 4087 gene, also known as SMAD family member 2, JV18, MADH2, MADR2, JV18-1, hMAD-2, and hSMAD2. ABfinity™ recombinant rabbit anti-SMAD2 monoclonal antibody is used in Western Blot, Immunofluorescence, Flow Cytometry and ChIP.Antibody Specifications:• Applications: Validated applications for rabbit anti-SMAD2 monoclonal antibody are Western Blot, Immunofluorescence, Flow Cytometry and ChIP.• Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG.• Clone ID of Monoclonal Antibody (mAb): The rabbit anti-SMAD2 monoclonal antibody clone is 31H15L4.• Reactivity: Reacts with human SMAD2.• Product Size: Rabbit anti-SMAD2 monoclonal antibody is available in a 100 µg size. Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Members of the Smad family transmit TGF-β signals from the cell surface into the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smads (co-Smads), including Smad4, and the antagonistic or inhibitory Smads (I-Smads), including Smad6 and Smad7. Impaired Smad2 activity has been linked to TGF-β resistance in multiple myeloma through the activation of CDKs. Aberrant activation of CDKs results in phosphorylation of Thr8 and subsequent inactivation of Smad2, preventing Smad2-Smad4 interaction resulting in loss of transcriptional regulation by Smad2. 规格

Reactivity:	Human
Validated Application:	Flow Cytometry,Western Blot,Chromatin Immunoprecipitation,Immunofluorescence,ELISA
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	31H15L4
Antibody Fragment:	Whole Antibody
Target Gene:	Smad2
Gene ID:	4087
Accession Number:	Q15796
Label or Dye:	Unconjugated
Purification:	Affinity Purified
Concentration:	0.5 mg⁄ml
Color:	Unconjugated
Form:	Liquid
Neutralizing Antibody:	No
Platform:	Fluorescence Microscope,Confocal Microscope,Flow Cytometer
Product Size:	100 µg
Quantity:	1
Volume:	200 µl
Shipping Condition:	Wet Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.