货号：700113

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UG

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ recombinant rabbit anti-TAK1 monoclonal antibody is specific to human TAK1 (MAP3K7). TAK1 (MAP3K7) is a versatile protein with many signaling functions. TAK1 is encoded by the 6885 gene, also known as TAK1, MEKK7, and TGF1-α. This rabbit anti-TAK1 monoclonal antibody is used in western blotting, immunocytochemistry, immunofluorescence, and flow cytometry applications.Antibody Specifications:• Applications: Validated applications for this monoclonal antibody are western blotting, flow cytometry, and immunofluorescence.• Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG.• Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 28H25L68.• Reactivity: Reacts with human TAK1.• Product Size: Rabbit anti-TAK1 monoclonal antibody is available in a 100 µg size. TAK1 (MAP3K7) is a versatile protein with many signaling functions. Originally identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β-receptor and TRAF6 to modulate TGF-β activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin β1 and integrin β5, promoting proper wound healing.TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 becomes autophosphorylated at Thr178, Thr184, Thr187, and Ser192. TAK1 phosphorylates IKK-β. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan. 规格

Reactivity:	Human
Validated Application:	Flow Cytometry,Immunofluorescence,Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	28H25L68
Antibody Fragment:	Whole Antibody
Target Gene:	TAK1
Gene ID:	6885
Accession Number:	O43318
Label or Dye:	Unconjugated
Purification:	Affinity Purified
Concentration:	0.5 mg⁄ml
Color:	Unconjugated
Neutralizing Antibody:	No
Platform:	Fluorescence Microscope,Confocal Microscope,Flow Cytometer
Product Size:	100 µg
Quantity:	1 each
Volume:	200 µl
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.