货号：700178

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UG

目录价：￥4701.00

市场价格：￥4230.90

会员价格：￥4230.90

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ Recombinant Rabbit anti-claudin-18 monoclonal antibody is specific to human and mouse claudin-18. Because of claudin-18's highly restricted expression pattern in normal tissues and frequent activation in numerous human cancers, claudin-18 may represent an important target for antibody therapy. Claudin-18 is encoded by the 51208 gene, also known as SFTA5, SFTPJ, CLDN18, and Claudin-18. Anti-claudin-18 monoclonal antibody is used in Western Blot, Immunofluorescence and Immunohistochemistry applications.Antibody Specifications:• Applications: Validated applications for Rabbit anti-Claudin-18 monoclonal antibody are Western Blot, Immunofluorescence and Immunohistochemistry.• Host Species and Isotype: The host species and isotype of the antibody is rabbit IgG.• Clone ID of Monoclonal Antibody (mAb): The monoclonal antibody clone is 34H14L15.• Reactivity: Reacts with human and mouse claudin-18.• Product Size: Rabbit anti-claudin-18 monoclonal antibody is available in a 100 µg size. Claudin-18 is a tight junction protein expressed as lung- and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear. Because of its highly restricted expression pattern in normal tissues and frequent activation in numerous human cancers, claudin-18 may represent an important target for antibody therapy. 规格

Reactivity:	Human,Mouse
Validated Application:	Western Blot,Immunofluorescence,Immunohistochemistry
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	34H14L15
Antibody Fragment:	Whole Antibody
Target Gene:	Claudin-18
Gene ID:	51208
Accession Number:	P56856
Label or Dye:	Unconjugated
Purification:	Affinity Purified
Concentration:	0.5 mg⁄ml
Color:	Unconjugated
Form:	Liquid
Neutralizing Antibody:	No
Platform:	Fluorescence Microscope,Confocal Microscope
Product Size:	100 µg
Quantity:	1
Volume:	200 µl
Shipping Condition:	Wet Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.