货号：700281

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UG

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ recombinant rabbit anti-NIK monoclonal antibody is specific to human NIK (MAP3K). Based on sequence similarity, reactivity to rhesus monkey, mouse, rat, bovine, equine, and chicken is expected. NIK, also known as mitogen-activated protein kinase kinase kinase (MAP3K) 14 is an NF-κB inducing protein kinase of the serine/threonine kinase family. This rabbit anti-NIK monoclonal antibody is used in western blotting and immunofluorescence applications.Antibody Specifications:• Applications: Validated applications for this rabbit anti-NIK monoclonal antibody are western blotting and immunofluorescence.• Host Species and Isotype: The host species and isotype of the antibody is rabbit anti-NIK.• Clone ID of Monoclonal Antibody (mAb): The rabbit anti-NIK monoclonal antibody clone is 3H31L48.• Reactivity: Reacts with human NIK (MAP3K).• Product Size: Rabbit anti-NIK monoclonal antibody is available in a 100 µg size. NIK, also known as mitogen-activated protein kinase kinase kinase (MAP3K) 14 is an NF-κB inducing protein kinase of the serine/threonine kinase family. NIK binds to Traf2 to activate NF-κB as part of a signaling cascade involving receptors of the TNF/NGF family and the interleukin-1 type-I receptor. NIK protein is shuttled between cytosolic, nuclear, and nucleolar compartments. When shuttled to the nucleolus, NIK-dependant NF-κB activation is impaired relative to its nuclear localization revealing a possible means of regulation. Reactive oxygen species can interact directly with NIK to alter NF-κB activation. Additionally, NIK specifically interacts with Down Syndrome Candidate Region 1 (DSCR1) blocking its proteosomal degradation leading to DSCR1 accumulation and cytotoxicity. 规格

Reactivity:	Human
Validated Application:	Western Blot,Immunofluorescence
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	3H31L48
Antibody Fragment:	Whole Antibody
Target Gene:	NIK
Gene ID:	9020
Accession Number:	Q99558
Label or Dye:	Unconjugated
Purification:	Affinity Purified
Concentration:	0.5 mg⁄ml
Form:	Liquid
Neutralizing Antibody:	No
Product Size:	100 µg
Quantity:	1 each
Volume:	200 µl
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.