货号：701048

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：EACH

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ recombinant rabbit monoclonal antibody recognizes C-Jun N-terminal Kinase (JNK) in human samples.ABfinity™ antibody characteristics include:• Validation in Western blot and indirect ELISA• Superior lot-to-lot consistency• Extremely high specificity and sensitivity• Recombinant rabbit monoclonal antibodySpecific for JNK C-Jun N-terminal Kinase (JNK), also known as Mitogen-activated protein kinase (MAPK8), belongs to the MAPK superfamily, a stress-activated protein kinase family that includes JNK, ERK, and p38 MAP kinases. MAPKs are serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus (Ref 1). JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. JNK and p38 MAPK pathways are activated by stress and inflammatory signals (Ref 2, 3). JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2 (Ref 4).Exceptional Consistency Saves You Time and MoneyABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.High Specificity Means More Reliable DataThe proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in Western blotting.High Sensitivity Lets You Detect Low Levels of Target ProteinABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.Recombinant Rabbit IgG—Use Like Any Other IgG AntibodyAs with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.Related Links:Learn more about the superior performance of ABfinity™ recombinant monoclonal antibodies.See Invitrogen's full line of ABfinity™ recombinant monoclonal antibodies.References:• Himes SR, Sester DP, Ravasi T, Cronau SL, Sasmono T, Hume DA. The JNK are important for development and survival of macrophages. J Immunol. 2006 Feb 15;176(4):2219-28. PubMed PMID: 16455978.• Zhou JY, Liu Y, Wu GS. The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death. Cancer Res. 2006 May 1;66(9):4888-94. PubMed PMID: 16651445.• Ventura JJ, Cogswell P, Flavell RA, Baldwin AS Jr, Davis RJ. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev. 2004 Dec 1;18(23):2905-15. PubMed PMID: 15545623.• Liu J, Minemoto Y, Lin A. c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol. 2004 Dec;24(24):10844-56. PubMed PMID: 15572687. 规格

Reactivity:	Human
Validated Application:	ELISA,Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	2H15L8
Antibody Fragment:	Whole Antibody
Target Gene:	JNK
Gene ID:	5599
Gene Symbol:	MAPK8
Accession Number:	P45983
Label or Dye:	Unconjugated
Purification:	Purified
Concentration:	0.5 mg⁄ml
Form:	Liquid
Neutralizing Antibody:	No
Product Size:	100 µg
Protein Family:	Kinases & Inhibitors
Research Category:	Signal Transduction
Shipping Condition:	Wet Ice

内容及储存 2 - 8°C for up to 1 month -20°C for long storage Avoid repeated freezing and thawing.