货号：701057

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：EACH

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ recombinant rabbit monoclonal antibody recognizes p38 MAPK [pTpY180/182] in human samples.ABfinity™ antibody characteristics include:• Validation in Western blot and indirect ELISA• Superior lot-to-lot consistency• Extremely high specificity and sensitivity• Recombinant rabbit monoclonal antibodySpecific for p38 MAPK [pTpY180/182] p38 Mitogen-activated protein kinases, also known as SAPK2 (Stress-Activated Protein Kinase 2), belongs to the mitogen-activated protein kinase family, which is responsive to stress stimuli. The mammalian p38 MAPK families are activated by cellular stress including UV irradiation, heat shock, high osmotic stress, lipopolysaccharide, protein synthesis inhibitors, proinflammatory cytokines (such as IL-1 and TNF-alpha), and certain mitogens, which may lead to autoimmunity. There are four p38 kinases - α, β, γ and δ. p38α is well characterized and is expressed in most cell types. The p38 MAPK subfamily plays important roles in cytokine production and the stress response. Additional functions for p38 MAPKs are in the inhibition of cell cycle progression, developmental processes, and the differentiation of several vertebrate cell types. An important target of the p38 MAP kinase is the tumor suppressor protein p53, whose activation is positively regulated by p38. MKK3, MKK6, and SEK phosphorylate p38 MAPK at threonine 180 and tyrosine 182. Phosphorylation of these residues activates p38 MAPK which in turn activates and phosphorylates ATF1, ATF2, and ATF6.Exceptional Consistency Saves You Time and MoneyABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.High Specificity Means More Reliable DataThe proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in Western blotting.High Sensitivity Lets You Detect Low Levels of Target ProteinABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.Recombinant Rabbit IgG-Use Like Any Other IgG AntibodyAs with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.Related Links:Learn more about the superior performance of ABfinity™ recombinant monoclonal antibodies.See Life Technologies' full line of ABfinity™ recombinant monoclonal antibodies. 规格

Reactivity:	Human
Validated Application:	ELISA,Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	B10H8L5
Antibody Fragment:	Whole Antibody
Target Gene:	p38 MAPK [pTpY180/182]
Gene ID:	1432
Gene Symbol:	MAPK14
Accession Number:	Q16539
Label or Dye:	Unconjugated
Purification:	Purified
Concentration:	0.5 mg⁄ml
Form:	Liquid
Neutralizing Antibody:	No
Product Size:	100 µg
Protein Family:	Kinases & Inhibitors
Research Category:	Signal Transduction
Shipping Condition:	Wet Ice

内容及储存 2 - 8°C for up to 1 month -20°C for long storage Avoid repeated freezing and thawing.