货号：11-0493-83
品牌：eBioscience (含Bender)
规格：200 ug
目录价：￥3367.00
市场价格：￥2861.95
会员价格：￥2794.61
金山科研平台，产品价格货期咨询微信：jinshanbio
Description: The eBioHMα5-1 monoclonal antibody reacts with mouse and rat CD49e, also known as integrin α5 or VLA-5A. CD49e is a member of the integrin α chain family, and binds with CD29 (integrin β1) to form the receptor VLA-5, which binds the ligands fibronectin and fibrinogen. CD49e is a type I, single-pass membrane protein, with a molecular weight of 135 kDa, and is expressed on multiple cell types including thymocytes, mast cells, activated T cells and splenic B cells. In addition to its role in adhesion, VLA-5 contributes to T-cell co-stimulation. The eBioHMα5-1 monoclonal antibody has been demonstrated to interfere with VLA-5-mediated cell adhesion, and with the degranulation of IgE-sensitized rat RBL cells stimulated on fibronectin-coated plates. Furthermore, HMα5-1 injected into mice subcutaneously, along with anti-CD49d and anti-CD61, is able to inhibit passive cutaneous anaphylaxis.
| Host |
Armenian Hamster |
|---|
| Isotype |
IgG |
|---|
| Reactivity |
Mouse, Rat |
|---|
| Conjugate |
FITC |
|---|
| Laser |
Blue Laser |
|---|
| Emit |
518 nm |
|---|
| Excite |
488 nm |
|---|
| Reported Applications |
Flow Cytometric Analysis |
|---|
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