eBioscience (含Bender)代理12-1529-41 Anti-Human CD152 (CTLA-4) PE 25 tests；价格见Thermo同编号产品-试剂-金山科研平台

eBioscience (含Bender)代理12-1529-41 Anti-Human CD152 (CTLA-4) PE 25 tests；价格见Thermo同编号产品

2025-06-27

货号：12-1529-41

品牌：eBioscience (含Bender)

规格：25tests

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio

Description: The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.The 14D3 antibody also recognizes rhesus monkey and has inhibitor activity.

Host	Mouse
Isotype	IgG2a, kappa
Reactivity	Human, Rhesus
Conjugate	PE
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Excite	488 - 561 nm
Reported Applications	Flow Cytometric Analysis

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