Merck Millipore代理402081-1MGCN Indirubin Derivative E804-试剂-金山科研平台

Merck Millipore代理402081-1MGCN Indirubin Derivative E804

2025-06-28

货号：402081-1MGCN

品牌：Merck Millipore

规格：EA

目录价：￥1210.00

市场价格：￥1028.50

会员价格：￥968.00

金山科研平台，产品价格货期咨询微信：jinshanbio

Overview	A cell-permeable indirubin derivative (IDR) that blocks the Src-Stat3 signaling pathway and displays anti-tumor properties. Shown to be a potent, reversible, and ATP-competitive inhibitor of the kinase activities of Src (IC50= 430 nM), Cdk1/cyclin E (IC50= 210 nM), Cdk2/cyclin A (IC50= 540 nM), and Cdk1/cyclin B (IC50= 1.65 µM). Reduces the tyrosine phosphorylation levels of Src, JAK1, and Stat3 in MDA-MB-468 cells in a time- and dose-dependent manner. Selectively induces apoptosis in cells expressing high levels of active Stat3, but not cells lacking activated Stat3. The apoptotic effect of E804 is shown to be due to the down-regulation of antiapoptotic proteins Mcl-1 and survivin.
Catalogue Number	402081
Brand Family	Calbiochem®
Synonyms	IDR E804

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