货号：340425

品牌：BD IS

规格：50T

目录价：￥3766.00

市场价格：￥2636.20

会员价格：￥2447.90

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Catalog Number

340425

Name

CD27

Size

50Tests

RegulatoryStatus

RUO (GMP)

Clone

L128

Format

PE

Isotype

IgG₁, κ

W.S. No

6T-037

W.B. Positive Control

none

Immunogen

Human Activated Peripheral Blood Cells

Strain Host

BALB/c

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested

Clone - Description

CD27 recognizes a 55-kDa disulfide-linked dimer that is a member of the nerve growth factor (NGF) superfamily, which also includes CD40, rat Ox 40, tumor necrosis factor (TNF) receptors α and β, and CD95 (Fas). With its ligand CD70, CD27 acts in a co-stimulatory fashion on T lymphocytes.Present on most peripheral blood T lymphocytes and medullary thymocytes, the CD27 antigen is upregulated upon activation with the release of a soluble form, 28 to 32 kDa. It is also detected on a subpopulation of approximately 33% of circulating B lymphocytes. Following exposure to antigens, CD45RA⁺ T lymphocytes respond by upregulating the CD27 antigen. After maximal stimulation, the CD27 antigen cannot be re-expressed on long-term cultures or on CD45RA^-CD27⁺ T lymphocytes. The CD4⁺CD27^- population is contained within the memory CD45RO⁺ subset that proliferates after exposure to allergens. Two subpopulations of B lymphocytes bearing the CD27 antigen secrete IgM (δ⁺) and IgG (δ^-).