货号：340510

品牌：BD IS

规格：50T

目录价：￥5707.00

市场价格：￥3994.90

会员价格：￥3709.55

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Catalog Number

340510

Brand

BD FastImmune™

Name

IL-8

Size

50Tests

RegulatoryStatus

RUO (GMP)

Clone

AS14

Format

PE

Isotype

IgG₁, κ

W.S. No

none

W.B. Positive Control

none

Molecular Weight

none

Reactivity

QC Testing : Human

Applications

Flow cytometry	- Routinely Tested
Intracellular Staining	- Routinely Tested

Clone - Description

Anti-Human Interleukin-8 (Anti-Hu–IL-8) recognizes a nonglycosylated protein of approximately 8 kDa.Human IL-8 (previously known as neutrophil attractant/activating protein, NAP-1, and as monocyte-derived neutrophil chemotactic factor, MDNCF) is a member of a superfamily of proinflammatory cytokines that have been termed chemokines because they are chemo-attractants for leucocytes. Chemokines are 70- to 80-residue proteins with four conserved cysteines. IL-8 is designated as a CXC chemokine due to an amino acid separating the first two of four conserved cysteines. IL-8 is a homodimer in solution. There are two major forms of IL-8: a 72-amino acid form (72-AA), and a 77-amino acid form (77-AA). While both forms are biologically active, the 72-AA form is produced primarily by monocytes and is more potent than the 77-AA form which is produced mainly by endothelial cells.IL-8 is a chemoattractant for neutrophils, T lymphocytes, and basophils. It activates neutrophils, and it possesses angiogenic activity. IL-8 is primarily produced and secreted by monocytes, but it is also expressed by endothelial cells, fibroblasts, keratinocytes, T lymphocytes, LGLs, B-chronic lymphocytic leukemia (B-CLL) cells, and human malignant melanoma cells. Phagocytosing neutrophils produce and release high amounts of IL-8. IL-8 is produced by monocytes in response to IL-1b, TNF-a, lipopolysaccharide (LPS), and PHA. Lymphocyte-derived IL-4 and monocyte-derived IL-10 inhibit the production of IL-8 by monocytes. IL-8 response to LPS is relatively short lived. A more sustained, secondary response is elicited in response to TNF-a and IL-1.