货号：340529

品牌：BD IS

规格：

目录价：￥2882.00

市场价格：￥2017.40

会员价格：￥1873.30

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Catalog Number

340529

Name

CD117

Alias

c-kit

Size

50Tests

RegulatoryStatus

RUO (GMP)

Clone

104D2

Format

PE

Isotype

IgG₁, κ

W.S. No

VI C30

W.B. Positive Control

none

Immunogen

Megakaryoctic cell line MOLM-1

Strain Host

BALB/c

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested

Clone - Description

CD117 binds to the receptor for stem cell factor (SCF). It selectively recognizes NIH-3T3 cells transfected with human c-kit, the gene that codes for SCF-R. CD117 antibody does not block the epitope that binds SCF.In the bone marrow of humans and mice, SCF is expressed primarily on hematopoietic progenitor cells. Lack of functional SCF or deficient SCF-R caused by mutations in the Sl and W loci, respectively, can result in severe anemia and a decrease in the number of primitive progenitor cells in mice. Human hematopoietic progenitor cells can be recognized by their surface expression of CD34. This cell population constitutes a small subset (1% to 5%) of bone marrow cells. CD34⁺ cells contain a small subpopulation of primitive/non-committed progenitors, with the remaining fraction being cells committed to the various hematopoietic lineages.SCF alone induces extensive proliferation of erythroid-committed progenitor cells (CD34^loCD71^hiCD64^-). On primitive (CD34^hiCD38^loCD50⁺) and granulo-monocytic (CD34⁺CD64⁺) progenitor cells, SCF synergistically enhances the effects of other cytokines, the strongest of which are on the primitive progenitor cells. In addition, SCF promotes survival of primitive progenitors in the absence of proliferation. The receptor is highly expressed at similar levels on all of the three mentioned CD34⁺ cell subsets, whereas B-lymphoid committed progenitor cells (CD34⁺CD19⁺) express low levels of SCF-R. Among CD34^- bone marrow cells, only a small number of cells (mostly erythroid) express the receptor.