货号：340976

品牌：BD IS

规格：200ug

目录价：￥3424.00

市场价格：￥2396.80

会员价格：￥2225.60

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Catalog Number

340976

Name

CD49d

Alias

Integrin α₄ chain

Size

200µg

RegulatoryStatus

RUO (GMP)

Clone

L25

Format

Purified

Isotype

IgG_2b, κ

W.S. No

none

W.B. Positive Control

none

Molecular Weight

none

Reactivity

QC Testing : Human

Applications

Flow cytometry	- Routinely Tested
Immunohistochemistry	- Routinely Tested

Clone - Description

CD49d (Anti–VLA-a4) recognizes the 150-kDa a chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of a and b subunits and is involved in cell-cell and cell-extracellular matrix interactions. The b chain of the VLA-4 complex is the CD29 antigen, a 130-kDa glycoprotein. The CD29 antigen, also known as the b1 subunit, is common to the VLA family of integrins.When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with an as-yet-undefined b subunit, may act as a Peyer`s patch-specific lymphocyte homing receptor. The CD49d antigen is also involved in CD3-dependent CD4⁺ T-lymphocyte activation via its interaction with fibronectin.The CD49d antigen is expressed primarily on T and B lymphocytes and weakly on monocytes.