货号：347637

品牌：BD IS

规格：100T

目录价：￥4565.00

市场价格：￥3195.50

会员价格：￥2967.25

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Catalog Number

347637

Name

CD11c

Alias

Integrin α^X chain

Size

100Tests

RegulatoryStatus

RUO (GMP)

Clone

S-HCL-3

Format

PE

Isotype

IgG_2b, κ

W.B. Positive Control

none

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested

Clone - Description

CD11c recognizes a human monocyte/ macrophage antigen. CD11c is specific for the Mr 150-kDa α-subunit of the CD11c/CD18 antigen heterodimer, also referred to as complement receptor type 4 (CR₄). The Mr 95-kDa CD18 antigen, the β chain of leucocyte function–associated antigen-1 (LFA-1), is common to the CD11a/CD18 (LFA-1) and CD11b/CD18 antigen heterodimers.The CD11c antigen is present on monocytes and in low density on granulocytes and NK lymphocytes in peripheral blood. It is also present on hairy-cell leukemias and on some acute myeloid leukemias (AML). CD11c reacts with an epitope on the α (150-kDa) chain of the CD11c/CD18 antigen complex. In addition, CD11c stains sinus histiocytes of lymph node, tonsil, and spleen; macrophages in the cortex and medulla of thymus; Kupffer cells in liver; elongated intertubular cells in kidney; and alveolar macrophages in lung tissue. In malignant tissue, the antibody stains true histiocytic lymphomas. It does not stain carcinomas or T or B lymphomas.