货号：347687

品牌：BD IS

规格：

目录价：￥4520.00

市场价格：￥3164.00

会员价格：￥2938.00

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Catalog Number

347687

Name

CD38

Size

100Tests

RegulatoryStatus

RUO (GMP)

Clone

HB7

Format

PE

Isotype

IgG₁, κ

W.S. No

III B918

W.B. Positive Control

none

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested

Clone - Description

CD38 recognizes an integral membrane glycoprotein, Mr 45 kDa, with a protein core of 35 kDa.The CD38 antigen is expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. It is also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. The antigen is expressed during the early stages of T- and B-lymphocyte differentiation, is lost during the intermediate stages of maturation, and then reappears during the final stages of maturation. The CD38 antigen is expressed on 90% of CD34⁺ cells and is not expressed on pluripotent stem cells. Coexpression of CD38 antigen on CD34⁺ cells indicates lineage commitment of those cells. It is also expressed in T- and B-acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), Burkitt`s lymphoma, multiple myeloma, and acute myeloid leukemia (AML).In HIV infection, the coexpression of the CD8 and CD38 antigens, with a concomitant low percentage of CD4⁺ lymphocytes, is closely associated with disease progression. Beginning at seroconversion, and during the first stages of HIV infection, the number of CD8⁺ T lymphocytes increases while the number of CD4⁺ T lymphocytes decreases. When the onset of acquired immune deficiency syndrome (AIDS) occurs, there is a declince in the absolute CD3⁺, CD4⁺, and CD8⁺ lymphocyte levels along with a further decrease in the CD4⁺ T-lymphocyte percentage. The relative percentage of CD8⁺ T lymphocytes continues to rise until, in the late stages of AIDS, the majority of the remaining T lymphocytes are CD8⁺. Elevated levels of CD8⁺CD38⁺ T lymphocytes become apparent at the time of seroconversion and continue to rise throughout the course of the disease, indicating persistent stimulation of the immune system by the virus.