货号：347983

品牌：BD IS

规格：100T

目录价：￥4565.00

市场价格：￥3195.50

会员价格：￥2967.25

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Catalog Number

347983

Name

CD11a

Alias

Integrin α^L chain, LFA-1α

Size

100Tests

RegulatoryStatus

RUO (GMP)

Clone

G-25.2

Format

FITC

Isotype

IgG_2a, κ

W.S. No

none

W.B. Positive Control

none

Molecular Weight

none

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested

Clone - Description

CD11a (Anti–LFA-1a) recognizes the Mr 180-kDa a chain of the leucocyte function–associated antigen-1 (LFA-1). LFA-1, a member of a subfamily of integrin receptors, is a leucocyte adhesion receptor that binds to an intercellular adhesion molecule (ICAM) on target tissues. This subfamily consists of three heterodimeric proteins that share a common noncovalently-associated b chain (CD18 antigen, Mr 95 kDa) but possess distinct a-subunits recognized by CD11a (Anti–LFA-1a), CD11b, and CD11c.The CD11a antigen is expressed on virtually all normal peripheral blood leucocytes. It is essential for many immune responses that require cell-to-cell contact, such as lymphocyte adhesion, NK and T-lymphocyte cytolysis, and T-lymphocyte proliferation. Activation of lymphocytes through the T-cell antigen receptor (TCR) upregulates LFA-1 function, converting the antigen to a high-avidity state. Expression of LFA-1 on monocytes is upregulated by g-interferon (IFN-g). While normal cells possess both the a and b LFA-1 chains, cells of subjects with some leukemias, lymphomas, or leucocyte adhesion deficiency (LAD) may lack the entire LFA-1 molecule or the a or b chain. The absence of LFA-1 on tumor cells may provide a mechanism for their escape from immune surveillance.