货号：M-003537

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: HDAC3 RPD3-2A SMARTpool® siRNA reagent View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 5 nmol View All» Product Overview: For questions or concerns regarding the use of the SMARTpools®, please contact Dharmacon Technical Support, 1-800-235-9880, email: lab@dharmacon.com. View All» Application Notes: SMARTpools® are the collection of at least four individual siRNA duplexes targeted against a specific gene and designed using a bioinformatics technology known as SMARTselection™, resulting in the generation of siRNAs that function more than 97% of the time. The targeted message level is reduced by more than 70% 24 hours after transfection. For use in human cell lines. View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. View All» UniProt Summary: FUNCTION: SwissProt: O15379 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor.SIZE: 428 amino acids; 48848 Da SUBUNIT: Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1 and SRY. Interacts with BTBD14B. Interacts with GLIS2 (By similarity). Interacts with CBFA2T3.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Widely expressed.PTM: Sumoylated in vitro.SIMILARITY: SwissProt: O15379 ## Belongs to the histone deacetylase family. Type 1 subfamily. View All» Brand Family: Upstate View All» Sales Restrictions: This product is not available for sale in Japan. View All» UniProt Number: O15379 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Gene Symbol:

• HDAC3

• HD3

• SMAP45

• RPD3-2

• RPD3
  View All» Product Name: HDAC3 RPD3-2A SMARTpool® siRNA reagent View All» Entrez Gene Number: NM_003883.3 View All»
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