货号：MAB010-A/11

品牌：Merck Millipore

规格：EA

目录价：￥3182.00

市场价格：￥2704.70

会员价格：￥2545.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Apolipoprotein A-I Antibody, clone 412 | MAB010-A/11 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apolipoprotein A-I. No cross reactivity to Apo A-II or Apo B. AFFINITY CONSTANT: 6 X 10E8 View All» Immunogen: Pure apolipoprotein A-I isolated from HDL (1.065-1.21 gm/mL) prepared by isoelectric focusing. View All» Clone: 412 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: RIA View All» Presentation: IgG fraction purified from mouse ascites by Protein A column chromatography. Liquid in PBS with 0.1% sodium azide, pH 7.4. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to six months after date of receipt. Do not store below -20°C or in dry ice as precipitation may occur. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P02647 View All» Entrez Gene Number: NM_000039.1 View All» Gene Symbol:

• APOA1

• ApoA-I

• preproapolipoprotein

• amyloidosis

• MGC117399

• Apo-AI
  View All» Alternate Names: ApoAI View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Radioimmunoassay View All» Entrez Gene Summary: This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. View All» UniProt Summary: FUNCTION: SwissProt: P02647 # Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).SIZE: 267 amino acids; 30778 Da SUBUNIT: Interacts with APOA1BP.SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine.PTM: Palmitoylated.DISEASE: SwissProt: P02647 # Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant. & Defects in APOA1 are a cause of the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by the absence of plasma HDL, accumulation of cholesteryl esters, premature coronary artery disease, hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. In HDLD1 patients, ApoA-I fails to associate with HDL probably because of the faulty conversion of pro-ApoA-I molecules into mature chains, either due to a defect in the converting enzyme activity or a specific structural defect in Tangier ApoA-I. & Defects in APOA1 are a cause of systemic non-neuropathic amyloidosis [MIM:105200]; also known as amyloidosis VIII or Ostertag-type amyloidosis. It is an autosomal dominant disorder characterized by generalized amyloid deposition.SIMILARITY: SwissProt: P02647 ## Belongs to the apolipoprotein A1/A4/E family. View All» Brand Family: Chemicon View All» Product Name: Anti-Apolipoprotein A-I Antibody, clone 412 | MAB010-A/11 View All» Concentration: 3.02 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µg View All» Format: Purified View All» Host: Mouse View All»
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