货号：MAB10001

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Mouse Anti-CUL7/PARC Antibody | MAB10001 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: CUL 7 is a large polypeptide containing a cullin domain, and interacts with ROC1. CUL 7 assembles an SCF-like E3 ubiquitin ligase complex, which consists of ROC1, Skp1, the Fbx29 F-box protein, and CUL 7. SCF complexes function to ubiquitinate specific proteins and target them for destruction by the proteasome. CUL 7 heterodimerises with its homolog p53-associated, parkin-like cytoplasmic protein (PARC). View All» Immunogen: Recombinant Protein View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number:
  • Q14999

  • Q8VE73
    View All» Entrez Gene Number: NM_025611.5 View All» Gene Symbol: CUL7 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q14999 # Component of a probable SCF-like E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteosomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity).SIZE: 1698 amino acids; 191161 Da SUBUNIT: Part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.TISSUE SPECIFICITY: Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts.DISEASE: SwissProt: Q14999 # Defects in CUL7 are the cause of 3M syndrome [MIM:273750]. 3M syndrome is an autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.SIMILARITY: SwissProt: Q14999 ## Belongs to the cullin family. & Contains 1 DOC domain. View All» Brand Family: Chemicon View All» Product Name: Mouse Anti-CUL7/PARC Antibody | MAB10001 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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