货号：MAB10003

品牌：Merck Millipore

规格：

目录价：￥5096.00

市场价格：￥4331.60

会员价格：￥4076.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HECTH9 Antibody, clone AX81 | MAB10003 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 480 kDa View All» Immunogen: Synthetic peptide cooresponding to amino acids 2530-2596 of human HectH9 {Adhikary, S. et al, 2005}. View All» Clone: AX81 View All» Background Information: Hecth9 is a E3 ubiquitin ligase and is believed to be involved in the ubiquitination of myc. The HectH9-mediated ubiquitination of Myc is required for transactivation of multiple target genes, recruitment of the coactivator p300, and induction of cell proliferation by Myc. View All» Species Reactivity: Human View All» Application Notes: Western Blot: antibody reacts with HectH9, approximately 450 kDa.Immunocytochemistry: reacts with methanol fixed cells at 1:200.Immunoprecipitation: immunoprecipitates endogenous HectH9 from HeLa cell extracts, {Adhikary, S. 2005}. View All» Quality Assurance: Routinely evaluated by FMAT View All» Purification Method: Ascites View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: 1 year at 2-8°C from date of shipment View All» UniProt Number: Q7Z6Z7 View All» Entrez Gene Number: NM_031407.3 View All» Gene Symbol:

• HUWE1

• KIAA1578

• KIAA0312

• MULE

• Mule

• UREB1

• LASU1

• 5430439H10Rik

• URE-B1

• OTTHUMP00000061860

• E3(Histone)

• Ib772

• ARF-BP1

• HSPC272

• HECTH9

• EC 6.3.2.-
  View All» Alternate Names:
  • HECT

  • UBA

  • WWE domain containing 1

  • Mcl-1 ubiquitin ligase E3

  • ARF binding protein 1

  • E3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» UniProt Summary: FUNCTION: SwissProt: Q7Z6Z7 # E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Also ubiquitinates the p53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene.SIZE: 4374 amino acids; 481891 Da SUBUNIT: Interacts with isoform p14ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity.SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Predominantly cytosolic or perinuclear in some colorectal carcinoma cells.TISSUE SPECIFICITY: Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas.DOMAIN:SwissProt: Q7Z6Z7 The HECT domain mediates inhibition of the transcriptional activity of p53.PTM: Phosphorylated on tyrosine; phosphorylation is probably required for its ability to inhibit TP53 transactivation (By similarity). & Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Belongs to the TOM1/PTR1 family. & Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. & Contains 1 UBA domain. & Contains 1 UIM (ubiquitin-interacting motif) repeat. & Contains 1 WWE domain. View All» Brand Family: Chemicon View All» Product Name: Anti-HECTH9 Antibody, clone AX81 | MAB10003 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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