货号：MAB10005

品牌：Merck Millipore

规格：100Ug

目录价：￥5985.00

市场价格：￥5087.25

会员价格：￥4788.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ABCA1 Antibody, clone AB.H10 | MAB10005 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognize specifically ABCA1 from human, mouse, and chicken. View All» Immunogen: Recombinant fragment, corresponding to amino acids 1800-2260 of Human ABCA1. View All» Clone: AB.H10 View All» Isotype: IgG1 View All» Background Information: Mutations in the ABCA1 gene are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI. View All» Species Reactivity:

• Chicken

• Human

• Mouse
  View All» Application Notes: ELISA Immunohistochemistry (Paraffin): 5 μg/mL. Perform heat mediated antigen retrieval in sodium citrate buffer (pH 6), before commencing with IHC staining protocol. Amplification with biotin-streptavidin may be required. Immunoprecipitation Western Blot: 1 μg/mL. Predicted molecular weight: 254 kDa.Optimal working dilutions must be determined by end user. View All» Presentation: Presented as a liquid in PBS, pH 7.4 with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stable at 4°C for 3 months. View All» UniProt Number: O95477 View All» Entrez Gene Number: NM_005502.2 View All» Gene Symbol:
  • ABCA1

  • MGC165011

  • HDLDT1

  • ABC1

  • TGD

  • CERP

  • membrane-bound

  • TD

  • ABC-1

  • MGC164864

  • FLJ14958
    View All» Alternate Names: ATP-binding cassette transporter 1; ABC-1; Cholesterol efflux regulatory protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. View All» UniProt Summary: FUNCTION: SwissProt: O95477 # cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.SIZE: 2261 amino acids; 254286 Da SUBUNIT: Interacts with MEGF10.TISSUE SPECIFICITY: Widely expressed, but most abundant in macrophages.DOMAIN: SwissProt: O95477 Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.PTM: Phosphorylation on Ser-2054 regulates phospholipid efflux.DISEASE: SwissProt: O95477 # Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. & Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.SIMILARITY: Belongs to the ABC transporter family. ABCA subfamily. & Contains 2 ABC transporter domains. View All» Brand Family: Chemicon View All» Product Name: Anti-ABCA1 Antibody, clone AB.H10 | MAB10005 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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