货号：MAB10054

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytochrome P450 3A4 Antibody, clone F24 P2 B10 | MAB10054 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Cytochrome P450 3A4. View All» Molecular Weight: The calculated molecular weight is approximately 57 kDa. The additional 43 kDa band is a NH2-terminal truncated cytochrome P450 CYP3A4. (Jeon, S., et al. (2008). Exp Mol Med. 40:254–260.) View All» Epitope: Unknown View All» Immunogen: Ovalbumin-conjugated linear peptide corresponding to human Cytochrome P450 3A4. View All» Clone: F24 P2 B10 View All» Isotype: IgG1κ View All» Background Information: Cytochromes P450 are a superfamily of isoenzymes present in a wide variety of life-forms including animals, plants, fungi and microorganisms. The widespread interest in P450 is justified by the enormous range of physiological processes which involve enzymes from this family. These include, but are not limited to, steroid metabolism, drug deactivation, procarcinogen activation and xenobiotic detoxification. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Human liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human liver tissue lysate.Western Blot Analysis: 2 µg/mL of this antibody detected Cytochrome P450 3A4 on 10 µg of human liver tissue lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P08684 View All» Entrez Gene Number: NP_059488 View All» Gene Symbol:

• CP33

• CP34

• CYP3A

• CYP3A3

• CYPIIIA3

• CYPIIIA4

• HLP

• HLp

• NF-25

• P450-PCN1

• P450C3

• P450PCN1
  View All» Alternate Names:
  • Albendazole monooxygenase

  • Albendazole sulfoxidase

  • Cytochrome P450 3A3

  • Nifedipine oxidase

  • P450-III, steroid inducible

  • Quinine 3-monooxygenase

  • Taurochenodeoxycholate 6-alpha-hydroxylase

  • cytochrome P450, family 3, subfamily A, polypeptide 4

  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3

  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4

  • glucocorticoid-inducible P450
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.CATALYTIC ACTIVITY: Quinine + NADPH + O2 = 3-hydroxyquinine + NADP+ + H2O.Taurochenodeoxycholate + NADPH + O2 = taurohyocholate + NADP+ + H2O.Lithocholate + NADPH + O2 = hyodeoxycholate + NADP+ + H2O.Albendazole + NADPH + O2 = albendazole S-oxide + NADP+ + H2O.COFACTOR: Heme group.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. TISSUE SPECIFICTY: Expressed in prostate and liver.INDUCTION: By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.SEQUENCE SIMILARITIES: Belongs to the cytochrome P450 family. View All» Product Name: Anti-Cytochrome P450 3A4, clone F24 P2 B10 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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