货号：MAB10064

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DLX3, clone 1E9 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 34 kDa View All» Immunogen: Recombinant human DLX3 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: O60479 View All» Entrez Gene Number: NM_005220.2 View All» Gene Symbol:
  • DLX3

  • TDO
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. View All» UniProt Summary: FUNCTION: SwissProt: O60479 # Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.SIZE: 287 amino acids; 31738 Da SUBCELLULAR LOCATION: Nucleus (Potential).DISEASE: SwissProt: O60479 # Defects in DLX3 are a cause of trichodentoosseous syndrome (TDO) [MIM:190320]. TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair. & Defects in DLX3 are a cause of amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism (AIHHT) [MIM:104510]. Amelogenesis imperfecta (AI) represents a group of developmental conditions affecting the structure and clinical appearance of the enamel of all or nearly all the teeth in a more or less equal manner. The enamel may be hypoplastic, hypomineralised or both, and affected teeth may be discoloured, sensitive or prone to disintegration. AI exists in isolation or associated with other abnormalities as part of a syndrome. AI enamel crowns are normal in size and shape. AIHHT is an autosomal dominant trait associated with enamel defects and enlarged pulp chambers.SIMILARITY: SwissProt: O60479 ## Belongs to the distal-less homeobox family. & Contains 1 homeobox DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-DLX3, clone 1E9 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
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