货号：MAB10090

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HNF4A, clone 1F12 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 50/55kDa View All» Immunogen: Recombinant human HNF4A View All» Isotype: IgG2a View All» Background Information: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: 1 year at 2-8°C from date of shipment View All» UniProt Number: P41235 View All» Entrez Gene Number:
  • NM_000457.3

  • NM_001030003.1

  • NM_001030004.1

  • NM_175914.3

  • NM_178849.1

  • NM_178850.1
    View All» Gene Symbol:
    • HNF4A

    • HNF4-alpha

    • HNF4a7

    • TCF

    • TCF14

    • HNF-4-alpha

    • NR2A21

    • FLJ39654

    • HNF4a8

    • HNF4

    • NR2A1

    • HNF4a9

    • MODY1

    • MODY
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. View All» UniProt Summary: FUNCTION: SwissProt: P41235 # Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine.SIZE: 474 amino acids; 52785 Da SUBUNIT: Homodimerization is required for HNF4-alpha to bind to its recognition site.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution.DISEASE: SwissProt: P41235 # Defects in HNF4A are the cause of maturity onset diabetes of the young type 1 (MODY1) [MIM:125850]; also shortened MODY-1. MODY [MIM:606391] is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age) and a primary defect in insulin secretion. The clinical phenotype of MODY1 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications.SIMILARITY: SwissProt: P41235 ## Belongs to the nuclear hormone receptor family. NR2 subfamily. & Contains 1 nuclear receptor DNA-binding domain.MISCELLANEOUS: Binds fatty acids. View All» Brand Family: Chemicon View All» Product Name: Anti-HNF4A, clone 1F12 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
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