货号：MAB10110

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DEAF1, clone 3C12 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 63kDa View All» Immunogen: Recombinant human DEAF1 View All» Clone: 3C12 View All» Isotype: IgG2a View All» Background Information: Deformed epidermal autoregulatory factor 1 (DEAF1), is involved in the down-regulation transcription of genes through binding to a motif which consists of multiple copies of TTC[CG]G. Additioanlly DEAF1 binds to the retinoic acid response element (RARE) and has been shown to activate the proenkephalin gene independently of promoter binding, possibly through protein-protein interaction. View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: O75398 View All» Entrez Gene Number: NM_021008.2 View All» Gene Symbol:
  • DEAF1

  • SPN

  • ZMYND5

  • NUDR

  • suppressin

  • Suppressin
    View All» Alternate Names: Deformed epidermal autoregulatory factor 1; Nuclear DEAF-1 related transcriptional regulator (NUDR); Suppressin; Zinc finger MYND domain containing View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: O75398 # Transcription factor that binds to sequence with multiple copies of TTC[CG]G present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. Activates the proenkephalin gene independently of promoter binding, probably through protein- protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.SIZE: 565 amino acids; 59327 Da SUBUNIT: Homodimer (Probable). Binds to LMO4 (via its C-terminus), LMO2 and CLIM2 (By similarity). May interact with the corepressor NCOR.SUBCELLULAR LOCATION: Nucleus. Note=Cytoplasmic in non-mucinous colorectal carcinoma. & Isoform 3: Secreted. Note=Secreted in some cell types. & Isoform 4: Secreted. Note=Secreted in some cell types.TISSUE SPECIFICITY: Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells.DISEASE:SwissProt: O75398 # Defects in DEAF1 could confer a growth advantage to the mutated cell that may have implications for the development and progression of neoplasia, e.g. in the case of colorectal adenocarcinomas (CRC).SIMILARITY: SwissProt: O75398 ## Contains 1 MYND-type zinc finger. & Contains 1 SAND domain. MISCELLANEOUS: Subcellular location in CRC (cytoplasmic or nuclear) is a prognostic factor that identifies a subgroup of patients with reduced survival. In addition, changes in the subcellular location correlates with the proliferative status of the cells. View All» Brand Family: Chemicon View All» Product Name: Anti-DEAF1, clone 3C12 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
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