货号：MAB10129

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SMAD4, clone 3E2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 60 kDa View All» Immunogen: Recombinant human SMAD4 View All» Isotype: IgG2a View All» Background Information: Smad 4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. Smad 4 is functionally distinct among the Smad family, and is required for the assembly and transcriptional activation of diverse, Smad-DNA complexes. Smad 4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-β, activin, and bone morphogenetic protein signaling responses. Smad 4 is frequently inactivated in pancreatic, biliary and colorectal tumors. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: 1 year at 2-8°C from date of shipment View All» UniProt Number: Q13485 View All» Entrez Gene Number: NM_005359.3 View All» Gene Symbol:
  • SMAD4

  • DPC4

  • hSMAD4

  • MADH4

  • JIP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q13485 # Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor.SIZE: 552 amino acids; 60439 Da SUBUNIT: May form trimers with receptor-regulated SMAD (R-SMAD). Interacts with ATF2, COPS5, DACH1, MSG1, SKI and TRIM33. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R- SMAD.DISEASE: SwissProt: Q13485 # Defects in SMAD4 are a cause of pancreatic carcinoma [MIM:260350]. & Defects in SMAD4 are a cause of juvenile polyposis syndrome (JPS) [MIM:174900]; also known as juvenile intestinal polyposis (JIP). JPS is an autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers. & Defects in SMAD4 are a cause of juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome (JP/HHT) [MIM:175050]. JP/HHT syndrome phenotype consists of the coexistence of juvenile polyposis (JIP) and hereditary hemorrhagic telangiectasia (HHT) [MIM:187300] in a single individual. JIP and HHT are autosomal dominant disorders with distinct and non- overlapping clinical features. The former, an inherited gastrointestinal malignancy predisposition, is caused by mutations in SMAD4 or BMPR1A, and the latter is a vascular malformation disorder caused by mutations in ENG or ACVRL1. All four genes encode proteins involved in the transforming-growth-factor- signaling pathway. Although there are reports of patients and families with phenotypes of both disorders combined, the genetic aetiology of this association is unknown. & Defects in SMAD4 may be a cause of colorectal cancer (CRC) [MIM:114500].SIMILARITY: SwissProt: Q13485 ## Belongs to the dwarfin/SMAD family. & Contains 1 MH1 (MAD homology 1) domain. & Contains 1 MH2 (MAD homology 2) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-SMAD4, clone 3E2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
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