货号：MAB10141

品牌：Merck Millipore

规格：EA

目录价：￥3059.00

市场价格：￥2600.15

会员价格：￥2447.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TLR8 Antibody, clone 3H2 | MAB10141 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody recognizes TLR8. View All» Molecular Weight: 120kDa View All» Immunogen: Recombinant human TLR8 View All» Clone: 3H2 View All» Isotype: IgG2bκ View All» Background Information: Toll like receptor 8 (TLR8) family in mammals is comprised of a family of transmembrane proteins which contain multiple leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domains. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120 kDa. View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Control: Human placenta lysate View All» Quality Assurance: Evaluated by western blot on human placenta lysate.Western Blot Analysis: 1-2 µg/mL of this antibody detected TLR8 in human placenta tissue lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH7.4), 150 mM NaCl, and 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9NR97 View All» Gene Symbol:

• TLR8

• MGC119600

• ORFNames=UNQ249/PRO286

• MGC119599
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. View All» UniProt Summary: FUNCTION: SwissProt: Q9NR97 # Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).SIZE: 1041 amino acids; 119828 Da SUBUNIT: Binds MYD88 via their respective TIR domains (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).TISSUE SPECIFICITY: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.SIMILARITY: SwissProt: Q9NR97 ## Belongs to the Toll-like receptor family. & Contains 24 LRR (leucine-rich) repeats. & Contains 1 TIR domain. View All» Brand Family: Chemicon View All» Product Name: Anti-TLR8 Antibody, clone 3H2 | MAB10141 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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