货号：MAB10601

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nix, clone ZN002 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody is specific for the Nix (Nip3-like protein X, BNIP3α, BNIP3L) protein. On Western blots, it identifies the target band at ~40-50 kDa. View All» Molecular Weight: 40-50 kDa View All» Immunogen: Synthetic peptide derived from the internal region of human, mouse and rat Nix proteins. View All» Clone: ZN002 View All» Isotype: IgG1κ View All» Background Information: Nix, also known as Nip3-like protein X, BNIP3α, Bcl-2/adenovirus E1B 19-kDa protein interacting 3-like, or Bcl-2/adenovirus E1B 19-kDa protein interacting 3α, is a member of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNIP) family of mitochondrial proteins. Nix is a functional homolog of BNIP3, which physically interacts with the endogenous apoptosis suppressor protein Bcl-2 and the adenovirus encoded E1B 19-kDa apoptosis suppressor protein. Nix may functionsimultaneously with BNIP3 to promote apoptosis and play a role in tumor suppression. Nix and BNIP3 have been shown to be induced by hypoxic conditions in human cell lines and tumor types. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Based on sequence homology, reactivity with rat is expected.Other species not tested. View All» Application Notes: Western Blotting: 0.5-1.0 μg/mLELISA: 0.1-1.0 μg/mL View All» Control: K562, P3 myeloma cell lysates View All» Purification Method: Protein A purfied View All» Presentation: This monoclonal antibody is supplied in PBS, pH 7.4, containing 0.1% sodium azide. View All» Storage Conditions: Freeze undiluted aliquots at -20°C for one year from date of shipment. View All» UniProt Number: O60238 View All» Entrez Gene Number: NM_004331.2 View All» Gene Symbol:
  • BNIP3L

  • BNIP3H

  • BNIP3a

  • NIP3L

  • NIX

  • Nix

  • BNIP3A
    View All» Alternate Names: Nip3-like protein X, BNIP2alpha, Bcl/adenovirus E1B 19-kDa protein interacting 3-like View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression. View All» UniProt Summary: FUNCTION: SwissProt: O60238 # Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3.SIZE: 219 amino acids; 23930 Da SUBUNIT: Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein.SUBCELLULAR LOCATION: Nucleus envelope. Endoplasmic reticulum. Mitochondrion.PTM: Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.SIMILARITY: SwissProt: O60238 ## Belongs to the NIP3 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Nix, clone ZN002 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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