货号：MAB1061

品牌：Merck Millipore

规格：100Ug

目录价：￥7164.00

市场价格：￥6089.40

会员价格：￥5731.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bone Sialoprotein II Antibody, C-terminus, clone ID1.2 | MAB1061 View All» Replaces: AB1855 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recombinant and native human bone sialoprotein II (BSPII). Does not react with osteopontin (BSPI) or osteonectin. View All» Epitope: C-terminus View All» Immunogen: Bone Sialoprotein isolated from human bones. View All» Clone: ID1.2 View All» Isotype: IgG1 View All» Background Information: Bone Sialoprotein II is one of the major noncollagenous proteins in the extracellular matrix of bone. It is a phosphorylated glycoprotein with an approximate molecular weight of 70 kDa. The protein has been found in osteoblasts and osteocytes. Diseases concerning bone turnover, pathological bone alterations, as well as the rapid increase of osteoporosis make it necessary to establish new markers. Bone Sialoprotein is discussed as a potential serum marker for monitoring bone remodeling. View All» Species Reactivity: Human View All» Non-Reactive Species:

• Bovine

• Pig

• Rat
  View All» Application Notes: Western blot: (1μg/mL) Immunohistochemistry on paraffin embedded tissue sections: (1μg/mL) Immunocytochemistry: (1:100) ELISA: (1μg/mL) RIA Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin from culture supernatant. Lyophilized from 50 mM TRIS, pH7.4. View All» Storage Conditions: Maintain lyophilized material at 2-8°C. Reconstitute with 100μL sterile distilled water and store at -20°C in undiluted aliquots up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P21815 View All» Entrez Gene Number: NM_004967.2 View All» Gene Symbol:
  • IBSP

  • BNSP

  • SP-II

  • BSP-II

  • BSP
    View All» Alternate Names: BSPII; Integrin-binding Sialoprotein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Radioimmunoassay

    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. View All» UniProt Summary: FUNCTION: SwissProt: P21815 # Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.SIZE: 317 amino acids; 35018 Da SUBCELLULAR LOCATION: Secreted.PTM: N-glycosylated; glycans consist of sialated and core- fucosylated bi-, tri- and tetraantennary chains. & O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.MISCELLANEOUS: It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite. View All» Brand Family: Chemicon View All» Product Name: Anti-Bone Sialoprotein II Antibody, C-terminus, clone ID1.2 | MAB1061 View All» Concentration: 1 mg/mL (after reconstitution) View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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