货号：MAB1148

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tie-2 Antibody, extracellular, clone 1E11DH | MAB1148 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: Purity: Greater than 95% by SDS-PAGE. 0.22 micron sterile filtered. View All» Specificity: Recognizes mouse Tie-2 Receptor. View All» Epitope: extracellular View All» Immunogen: The extracellular domain of mouse Tie-2 receptor. View All» Clone: 1E11DH View All» Isotype: IgG2a View All» Background Information: Tie-2 is an endothelial-specific receptor tyrosine kinase and a receptor for angiopoietin 1. It is a type I membrane protein that is expressed predominantly in the endothelium of actively growing blood vessels and may represent the earliest mammalian endothelial cell lineage marker. Tie-2 is likely involved in the regulation of endothelial cell proliferation and differentiation and may direct the special orientation of endothelial cells during the formation of blood vessels. View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 5 μg/mL. Recognizes a band migrating at approximately 140 kDa corresponding to mouse Tie-2. FACS: 10 μg/mL Immunoprecipitation: 10 μg/mL of lysate ELISA Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: placenta and lung tissue. View All» Presentation: Immunoglobulin purified by protein G affinity chromatography. Liquid in PBS, pH 7.4, containing 0.05% Bronidox as a preservative. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q02763 View All» Entrez Gene Number: NM_000459.2 View All» Gene Symbol:

• TEK

• CD202B

• TIE2

• VMCM1

• VMCM

• hTIE2

• CD202b

• TIE-2

• EC 2.7.10.1
  View All» Alternate Names: Angiopoietin-1 Receptor; p140 TEK View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Flow Cytometry

  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. View All» UniProt Summary: FUNCTION: SwissProt: Q02763 # This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.SIZE: 1124 amino acids; 125811 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.DISEASE:SwissProt: Q02763 # Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated, serpiginous channels.SIMILARITY: SwissProt: Q02763 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. & Contains 3 EGF-like domains. & Contains 3 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Tie-2 Antibody, extracellular, clone 1E11DH | MAB1148 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rat View All»
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