货号：MAB1283

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-c-Fos Antibody, clone CF2 | MAB1283 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: c-fos Oncoprotein. STAINING PATTERN: Nuclear View All» Immunogen: Synthetic peptide representing continuous antigenic site of predicted high antigenicity on the c-fos molecule. View All» Clone: CF2 View All» Isotype: IgM View All» Species Reactivity: Human View All» Application Notes: Suggested working dilution 1:40. Recommended to be used on fresh frozen tissue or acetone fixed material with immunoperoxidase technique. Not recommended for use on paraffin embedded tissue. Optimal working dilutions must be determined by end user. View All» Applications Not Recommended: Immunohistochemistry (Paraffin) View All» Control: POSITIVE CONTROL: Breast carcinoma or colon carcinoma View All» Presentation: Culture supernatant. Liquid containing 15 mM sodium azide. View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P01100 View All» Entrez Gene Number: NM_005252.2 View All» Gene Symbol:

• FOS

• G0S7

• c-fos
  View All» Alternate Names: G0/G1 Switch Regulatory Protein 7 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. View All» UniProt Summary: FUNCTION: SwissProt: P01100 # Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.SIZE: 380 amino acids; 40695 Da SUBUNIT: Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB (By similarity).SUBCELLULAR LOCATION: Nucleus.SIMILARITY: SwissProt: P01100 ## Belongs to the bZIP family. Fos subfamily. & Contains 1 bZIP domain. View All» Brand Family: Chemicon View All» Product Name: Anti-c-Fos Antibody, clone CF2 | MAB1283 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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