货号：MAB1307

品牌：Merck Millipore

规格：500Ug

目录价：￥2908.00

市场价格：￥2471.80

会员价格：￥2326.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Mouse anti-Human IgG1 Antibody, clone HP6001, Fc | MAB1307 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human IgG1 Fc. ELISA Specificity: (Hamilton et al., 1987) human IgG subclass 1- 100% human IgG subclass 2- 0.25% human IgG subclass 3- 0.01% human IgG subclass 4-0.01% Isoelectric Focusing: mean pI 8.0 View All» Epitope: Fc fragment View All» Clone: HP6001 View All» Isotype: IgG2b View All» Species Reactivity: Human View All» Application Notes: This antibody employed as both a capture antibody and a detection antibody for human IgG1 in enzyme linked immunosorbent assays, radio-immunoassay and EIA affinity immunoblots (Papadea et al., 1985; Hamilton, et al., 1987). Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P31994 View All» Entrez Gene Number:

• NM_001002273.1

• NM_001002274.1

• NM_001002275.1

• NM_004001.3
  View All» Gene Symbol:
  • FCGR2B

  • CDw32

  • CD32B

  • IGFR2

  • CD32

  • Fc-gamma-RIIb

  • FCG2

  • FcRII-b

  • FCGR2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Radioimmunoassay

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P31994 # Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.SIZE: 310 amino acids; 34044 Da SUBUNIT: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.DOMAIN: SwissProt: P31994 Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.DISEASE:SwissProt: P31994 # A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. View All» Brand Family: Chemicon View All» Product Name: Mouse anti-Human IgG1 Antibody, clone HP6001, Fc | MAB1307 View All» Concentration: 1.09 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µg View All» Format: Purified View All» Host: Mouse View All»
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