货号：MAB1342

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Collagen Type VI Antibody, clone F1-8 | MAB1342 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with collagen type VI from human. Specificity established by identical reaction in immunoprecipitation of labeled lysates of human osteosarcoma cells MG63 with a reference monclonal antibody to type VI collagen. MAB1342 precipitates a 140 kDa band and some dimers. The monclonal stains stroma of different organs with a pattern identical to that of the reference antibody. View All» Immunogen: SDS-insoluble extracts of human colon tissue. View All» Clone: F1-8 View All» Isotype: IgM View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: use with cryostat sections fixed with either acetone or 4% formaldehyde. Not tested on paraffin embedded tissues. Immunoprecipitation. Dot-blotting. Final working dilutions must be determined by end user. View All» Storage Conditions: Maintain at -20°C in aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P02462 View All» Entrez Gene Number: NM_001845.4 View All» Gene Symbol:

• COL4A1

• Arresten

• arresten
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Dot Blot

  • Immunoprecipitation

  • Immunohistochemistry
    View All» Entrez Gene Summary: This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. View All» UniProt Summary: FUNCTION: SwissProt: P02462 # Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits endothelial cell proliferation and angiogenesis. Inhibits angiogenesis potentially via mechanisms involving cell surface proteoglycans and the alpha and beta integrins of endothelial cells.SIZE: 1669 amino acids; 160615 Da SUBUNIT: There are six type IV collagen isoforms, alpha 1(IV)- alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.TISSUE SPECIFICITY: Highly expressed in placenta.DOMAIN: SwissProt: P02462 Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G- X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.PTM: Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates. & Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. & The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.DISEASE: SwissProt: P02462 # Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant. & Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.SIMILARITY: Belongs to the type IV collagen family. & Contains 2 COL4C (collagen IV C-terminal) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Collagen Type VI Antibody, clone F1-8 | MAB1342 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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