货号：MAB13442

品牌：Merck Millipore

规格：

目录价：￥4528.00

市场价格：￥3848.80

会员价格：￥3622.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-13 Antibody, clone 181-14G11 | MAB13442 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reactive with latent (60 kDa) and active (48 kDa) forms of human MMP-13. Does not cross-react with human MMP-1, 2, 3, 7, 8 and 9. View All» Immunogen: Recombinant human MMP-13 View All» Clone: 181-14G11 View All» Isotype: IgG1κ View All» Species Reactivity: Human View All» Application Notes: Western blotSuggested concentration 1 μg/mL Immunohistochemistry on paraffin-embedded tissue sections, requires PLP fixation. Suggested concentration 2.5 μg/mL Optimal working dilutions must be determined by end user View All» Presentation: Purified immunoglobulin. Liquid containing 0.1M Na-Phosphate buffer, pH 7.0 containing 2% protease-free bovine serum albumin. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. View All» UniProt Number: P45452 View All» Entrez Gene Number: NM_002427.2 View All» Gene Symbol:

• MMP13

• MMP-13

• CLG3

• EC 3.4.24.-
  View All» Alternate Names: Collagenase-3 View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P45452 # Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 471 amino acids; 53820 Da TISSUE SPECIFICITY: Seems to be specific to breast carcinomas.DOMAIN: SwissProt: P45452 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.DISEASE: SwissProt: P45452 # Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia type 2 (SEMD2) [MIM:602111]; also known as spondyloepimetaphyseal dysplasia type Missouri. SEMDs are a heterogeneous group of skeletal disorders characterized by defective growth and modeling of the spine and long bones. The SEMDs are distinguished from the spondylometaphyseal dysplasias and the spondyloepiphyseal dysplasias by the combined involvement of the epiphyses and metaphyses. The 3 disorders have malformations of the vertebrae in common.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-13 Antibody, clone 181-14G11 | MAB13442 View All» Concentration: 2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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