货号：MAB13446

品牌：Merck Millipore

规格：100Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TIMP-2 Antibody, clone 2TMP05 | MAB13446 View All» Replaces: MAB13448 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB13446 recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinase-2 (TIMP-2). TIMP-2 is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. CHEMICON MAB13446 may be used to evaluate the invasive nature of some tumor types and determine the tissue distribution of TIMPs in other tumors such as adenomas and also its normal tissue. CELLULAR LOCALIZATION: Cytoplasmic View All» Immunogen: A synthetic peptide from the N-terminal region of human TIMP-2 protein. View All» Clone: 2TMP05 View All» Species Reactivity:

• Bovine

• Guinea Pig

• Human

• Mouse

• Rat

• Rabbit
  View All» Application Notes: Immunohistology (formalin/paraffin only): 2-4μg/ml 30 min at RT. Western blotting: 1μg/ml for 2 hrs at RT. (Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min. followed by cooling at RT for 20 min). The optimal dilution for a specific application under a given set of experimental conditions should be determined by the investigator. View All» Control: POSITIVE CONTROL: Pancreatic or colon carcinoma View All» Presentation: Purified from ascites fluid by Protein A chromatography. 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. View All» Storage Conditions: Antibody with sodium azide is stable for 12 months after date of receipt when stored at 2-8°C. View All» UniProt Number: P16035 View All» Entrez Gene Number: NM_003255.4 View All» Gene Symbol:
  • TIMP2

  • TIMP-2

  • CSC-21K
    View All» Alternate Names: Tissue Inhibitor of Metalloproteinase-2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. View All» UniProt Summary: FUNCTION: SwissProt: P16035 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.SIZE: 220 amino acids; 24399 Da SUBCELLULAR LOCATION: Secreted.PTM: The activity of TIMP2 is dependent on the presence of disulfide bonds.SIMILARITY: SwissProt: P16035 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain. View All» Brand Family: Chemicon View All» Product Name: Anti-TIMP-2 Antibody, clone 2TMP05 | MAB13446 View All» Concentration: 200 μg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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