货号：MAB1379

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD54 Antibody, extracellular, clone 84H10 | MAB1379 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes the extracellular D1 domain of ICAM-1. Blocks binding of LFA-1 and P. falciparum to ICAM-1. Reacts with the ICAM-1 antigen found in low levels on lymphocytes and strongly expressed on monocytes and granulocytes. Detects an antigen of 90 kDa. View All» Epitope: extracellular View All» Immunogen: K562 cell line View All» Clone: 84H10 View All» Isotype: IgG1 View All» Background Information: This molecule is inducible to high levels by mitogenic lectins on lymphocytes and by IL-1beta or IFN gamma on other cell types such as fibroblasts and enthothelial cells. View All» Species Reactivity: Human View All» Non-Reactive Species: Canine View All» Application Notes: Flow Cytometry: Neat - 1:10. 10 μL of suggested dilution will label 10e6 cells. Immunohistochemistry on frozen tissue sections: 1:20-1:50. Does not work on paraffin embedded tissue sections. Immunoprecipitation: 5 μg/ 10e7 cells Adhesion Blocking; blocks ICAM-1 mediated adhesion to LFA-1. Optimal working dilutions must be determined by end user. View All» Applications Not Recommended: Immunohistochemistry (Paraffin) View All» Presentation: Affinity purified immunoglobulin. Liquid in Phosphate buffered saline, pH 7.4, containing 0.09% sodium azide. View All» Storage Conditions: Store at 2-8°C for up to 12 months from date of receipt. Alternatively, this antibody can be stored at -20ºC. Avoid repeated freeze-thaw cycles. View All» UniProt Number: P05362 View All» Entrez Gene Number: NM_000201.1 View All» Gene Symbol:

• ICAM1

• P3.58

• BB2

• CD54

• ICAM-1
  View All» Alternate Names: ICAM-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunoprecipitation

  • Immunohistochemistry

  • Affects Function
    View All» Entrez Gene Summary: ICAM1 (CD54) is typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. ICAM1 is also exploited by Rhinovirus as a receptor. View All» UniProt Summary: FUNCTION: SwissProt: P05362 # ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). In case of rhinovirus infection acts as a cellular receptor for the virus. Also acts as receptor for some coxsackieviruses.SIZE: 532 amino acids; 57825 Da SUBUNIT: Interacts with human herpesvirus 8 MIR2 protein (Probable).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.SIMILARITY: SwissProt: P05362 ## Belongs to the immunoglobulin superfamily. ICAM family. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-CD54 Antibody, extracellular, clone 84H10 | MAB1379 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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