货号：MAB1387Z

品牌：Merck Millipore

规格：

目录价：￥3990.00

市场价格：￥3391.50

会员价格：￥3192.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD11b Antibody, clone M1/70.15.1, azide free | MAB1387Z View All» Replaces: MAB88919 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes the murine alphaM integrin chain, which exists as a heterodimer with the beta2 integrin (Springer, 1979; Springer, 1990). The antibody stains polymorphonuclear cells, monocytes and NK cells. Variable activity is reported with tissue macrophages. M1/70.15.1 blocks iC3b binding to its receptor (Beller, 1982). View All» Immunogen: T cell enriched splenocytes from B10 mice View All» Clone: M1/70.15.1 View All» Isotype: IgG2b View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Flow Cytometry 1:50-1:100 Immunohistology on fresh frozen or acetone fixed tissues. Immunohistochemistry on paraffin embedded tissues fixed in PLP, methyl-carnoy, or 2% PFA; traditional 10% formalin fixation is problematic. Immunoprecipitation: use a rabbit anti-rat capture antibody rather than protein G or A. Functional/blocking of C3bi binding to its receptor. Optimal working dilutions must be determined by end user. View All» Applications Not Recommended: Immunohistochemistry (Paraffin) View All» Control: Spleen, Cerebellum (Microglia) View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse immunoglobulin in PBS containing no preservatives View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P11215 View All» Entrez Gene Number: NM_000632.3 View All» Gene Symbol:
  • ITGAM

  • MO1A

  • CD11b

  • MAC1A

  • CD11B

  • MAC-1

  • CR3A

  • MGC117044
    View All» Alternate Names:
    • IntegrinalphaM

    • Mac-1a

    • MAB1387
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Immunofluorescence

      • Immunohistochemistry

      • Immunoprecipitation

      • Affects Function
        View All» Entrez Gene Summary: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Some integrin alpha M proteins contain an inserted amino acid (Q, between AA positions 499 and 500) resulting from a 3bp shift in a splice acceptor that inserts the codon CAG; receptors with or without the extra amino acid are functionally indistinguishable View All» UniProt Summary: FUNCTION: SwissProt: P11215 # Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.SIZE: 1152 amino acids; 127179 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.DOMAIN: SwissProt: P11215 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-CD11b Antibody, clone M1/70.15.1, azide free | MAB1387Z View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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