货号：MAB1410

品牌：Merck Millipore

规格：100UL

目录价：￥4626.00

市场价格：￥3932.10

会员价格：￥3700.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin α6β1 Antibody, clone-5A | MAB1410 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Rat integrin alpha6beta1, mainly associated with epithelial cells. Does not react with rat fibroblasts. View All» Immunogen: Rat esophageal carcinoma cell line B2T View All» Clone: mAB-5A View All» Isotype: IgG1 View All» Species Reactivity: Rat View All» Application Notes: Flow Cytometry: 1:50 - 1:100 Immunohistochemistry: frozen sections ELISA Final working dilution must be determined by the end user. View All» Presentation: Ascites. Liquid, containing 0.09% sodium azide. View All» Storage Conditions: Maintain at 2°-8°C or -20°C, if preferable, for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P23229 View All» Entrez Gene Number:

• NM_000210.2

• NM_001079818.1
  View All» Gene Symbol:
  • ITGA6

  • VLA-6

  • ITGA6B

  • CD49f
    View All» Alternate Names: VLA-6 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunohistochemistry
      View All» Entrez Gene Summary: The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P23229 # Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.SIZE: 1130 amino acids; 126619 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).PTM: Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.DISEASE: "SwissProt: P23229 # Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA) [MIM:226730]; also known as aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive disease characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus."SIMILARITY: SwissProt: P23229 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin α6β1 Antibody, clone-5A | MAB1410 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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