货号：MAB1552

品牌：Merck Millipore

规格：1mL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myosin Antibody, ventricular heavy chain α/β, clone F26.2D11 | MAB1552 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes the LMM (light meromyosin) fragment of human ventricular myosin heavy chain (type alpha/beta) View All» Epitope: ventricular heavy chain alpha/beta View All» Immunogen: Human ventricular myosin View All» Clone: F26.2D11 View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Application Notes: Immunochemistry: undiluted to 1:10 Western blotting: 1:10 Optimal dilutions must be determined by the end user. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: Maintain frozen at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze/thaw cycles. View All» UniProt Number:

• P12883

• P13533
  View All» Entrez Gene Number: NM_000257.2 View All» Gene Symbol:
  • MYH7

  • Myosin-7

  • MYHCB

  • MyHC-beta

  • DKFZp451F047

  • CMH1

  • CMD1S

  • MGC138378

  • MPD1

  • MGC138376
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: MYH7 encodes the cardiac muscle beta (or slow) isoform of myosin. Changes in the relative abundance of MYH7 and MYH6 (the alpha, or fast, isoform of cardiac myosin heavy chain) correlate with the contractile velocity of cardiac muscle. Mutations in MYH7 are associated with familial hypertrophic cardiomyopathy. View All» UniProt Summary: FUNCTION: SwissProt: P13533 # Muscle contraction.SIZE: 1939 amino acids; 223690 Da SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.DOMAIN: SwissProt: P13533 The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.DISEASE: SwissProt: P13533 # Defects in MYH6 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]. Familial hypertrophic cardiomyopathy is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. & Defects in MYH6 are the cause of atrial septal defect type 3 (ASD3) [MIM:160710]. ASD is one of the most common forms of congenital heart malformation. It is characterized by incomplete closure of the wall between the atria, resulting in blood flow from the left to the right atria.SIMILARITY: Contains 1 IQ domain. & Contains 1 myosin head-like domain.MISCELLANEOUS: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). & The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase. View All» Brand Family: Chemicon View All» Product Name: Anti-Myosin Antibody, ventricular heavy chain α/β, clone F26.2D11 | MAB1552 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 1 mL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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