货号：MAB1636

品牌：Merck Millipore

规格：

目录价：￥2960.00

市场价格：￥2516.00

会员价格：￥2368.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11 | MAB1636 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human keratins 4, 5, 6, 8, 10, 13, 18.Reacts with intermediate filaments of many species up to Xenopus laevis. View All» Clone: C-11 View All» Isotype: IgG1 View All» Species Reactivity: Vertebrates View All» Application Notes: Immunocytochemistry on cultured cells (methanol/acetone fixed). Immunohistochemistry on frozen tissue. Suitable for use on paraffin embedded tissue (protease digestion may be necessary). Western blot. Optimal working dilutions must be determined by end user. View All» Presentation: Ascites fluid. View All» Storage Conditions: Store at -20ºC in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number:

• P19013

• P13647

• P02538

• P05787

• P13645

• P13646

• P05783
  View All» Entrez Gene Number: NM_002272.2 View All» Gene Symbol:
  • KRT4

  • Cytokeratin-4

  • Keratin-4

  • CK-4

  • CK4

  • CYK4

  • K4

  • FLJ31692
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. View All» UniProt Summary: FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.SIZE: 483 amino acids; 53704 Da SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). View All» Brand Family: Chemicon View All» Product Name: Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11 | MAB1636 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Pan-keratin antibody View All» Format: Ascites View All» Host: Mouse View All»
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      © Merck Millipore代理MAB1636 Ms X Keratin Pan (4,5,6,8,10,13,18)，产品报价联系微信jinshanbio